The National Institutes of Health (NIH) is a medical research agency that is part of the US Department of Health and Human Services. Comprising 27 institutes and centres, the NIH makes and funds discoveries to improve health and save lives. The NIH aims to maximise the value of research data by encouraging data sharing, facilitating innovation of research tools and methods, increasing statistical power, and improving research quality through validation and replication.
The Office of Data Science Strategy (ODSS) will coordinate GA4GH activities across NIH. ODSS leads the implementation of the NIH's overall data science strategy in order to modernise the NIH data resource ecosystem.

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| Title | Related Driver Projects and Organisations |
|---|---|
| All of Us Researcher Workbench | All of Us Research Program |
| Biomedical Research Hub (BRH) | Biomedical Research Hub (BRH) |
| ClinGen Knowledge-base | Clinical Genome Resource (ClinGen) |
| NCI Data Commons Framework | NIH National Cancer Institute (NCI) |
| NCPI Interoperability Projects and partners | NIH Cloud Platform Interoperability (NCPI) effort |
| NHLBI BioData Catalyst® (BDC) | NHLBI BioData Catalyst® (BDC) |
Associated Driver Projects
| Title | Thematic Area |
|---|---|
| All of Us Research Program | Rare Disease Cancer Complex Traits |
| Biomedical Research Hub (BRH) | Rare Disease Cancer Complex Traits Basic Biology |
| Clinical Genome Resource (ClinGen) | Rare Disease |
| Human Pangenome Project (HPP) | Rare Disease Cancer Complex Traits Basic Biology |
| Monarch Initiative | Rare Disease Cancer Complex Traits Basic Biology |
| National Cancer Institute Cancer Research Data Commons (NCI CRDC) | Cancer |
| NHLBI BioData Catalyst® (BDC) | Rare Disease Cancer Complex Traits Basic Biology |
| NIH Cloud Platform Interoperability (NCPI) effort | Rare Disease Cancer Complex Traits Basic Biology |
| Repository of the International Fetal Genomics Consortium (RIFGC) | Rare Disease Complex Traits |
| Variant Interpretation for Cancer Consortium (VICC) | Cancer |