Reproducibility of research is key to open science. Developed by the GA4GH Cloud Work Stream, the Workflow Execution Service (WES) API describes a standard protocol for running the same genomic data analysis in different environments and still obtaining the same results. Rather than attempting to transfer data across national and institutional bounds — a process that is cumbersome, resource-intensive, and limited by regulatory constraints — the WES API is part of a larger framework to seamlessly bring algorithms to genomic data.

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Benefits
- Sends the same workflow to different compute centres and receives reliable, consistent results
- Enhances reproducibility and reusability of genomic analyses
- Wraps around a variety of workflow types and engines
Target users
Data generators, data custodians, and developers
Announcements
| Title | Related Driver Projects and Organisations |
|---|---|
| ARGO Data Platform | ICGC ARGO |
| BRCA Exchange | BRCA Challenge |
| cwl-WES | ELIXIR Cloud and AAI |
| ELIXIR Cloud & AAI | ELIXIR Cloud and AAI |
| ELIXIR-Beacon | ELIXIR Beacon |
| EpiShare Platform | EpiShare |
| Human Cell Atlas (HCA) Data Portal | Human Cell Atlas |
| NCPI Interoperability Projects and partners | NIH Cloud Platform Interoperability (NCPI) effort |
| NHLBI TOPMed BioData Catalyst | Trans-Omics for Precision Medicine (TOPMed) |
| Omics AI | Autism Sharing Initiative |
Publications
| Title | Author(s) | Year |
|---|---|---|
| International federation of genomic medicine databases using GA4GH standards | 2021 |
Documents
| Date | Title |
|---|---|
| 12 March 2024 | 2024 Cloud Work Stream Roadmap |
| 14 September 2023 | Code of Ethics and Community Conduct (CECC) |
| 8 June 2020 | Cloud APIs comic (v4.0) |
Contributors
Don't see your name..?
Get in touch- Christopher LlanwarneWorkflow Execution Service (WES) LeadBroad Institute of MIT and Harvard, Cambridge, US
- Patrick MageeWorkflow Execution Service (WES) LeadDNAstack, Toronto
- Lee PangWorkflow Execution Service (WES) LeadAmazon Web Services, Ltd. (AWS), Seattle
- Jeremy AdamsOntario Institute for Cancer Research (OICR), Toronto, Canada
- Peter AmstutzCurii
- Salvador Capella-GutierrezBarcelona Supercomputing Center, Barcelona
- Dashrath ChauhanEMBL's European Bioinformatics Institute (EBI), Hinxton, UK
- James EddySage Bionetworks, Seattle
- Kyle FerriterBroad Institute of MIT and Harvard, Cambridge, US
- Marc FiumeDNAstack, Toronto
- Ian ForeNIH National Center for Biotechnology Information (NCBI)
- David GlazerVerily, South San Francisco, CA, USA
- Dean HartleyAutism Speaks, Princeton
- Alexander KanitzUniversity of Basel, Basel, Switzerland
- Venkat MalladiVerily, South San Francisco, CA, USA
- Tommi NyrönenCSC – IT CENTER FOR SCIENCE
- Brian O'ConnorNimbus Informatics
- Jimmy PayyappillyEMBL's European Bioinformatics Institute (EBI), Hinxton, UK
- Shaikh Farhan RashidUniversity Health Network, Toronto, Canada, Canadian Distributed Infrastructure for Genomics (CanDIG)
- Sarah SalahiBroad Institute of MIT and Harvard, Cambridge, US
- David SteinbergUniversity of California, Santa Cruz, Santa Cruz
- Jonathan TeddsELIXIR, International
- Susheel VarmaInformation Commissioner's Office
- Denis YuenOntario Institute for Cancer Research (OICR), Toronto, Canada
- Christina YungOntario Institute for Cancer Research (OICR), Toronto, Canada, Indoc Research, Toronto
Driver Projects
| Title | Thematic Area |
|---|---|
| BRCA Challenge | Rare Disease Cancer |
| European Joint Programme on Rare Disease (EJP RD) | Rare Disease |
| ELIXIR Beacon | Rare Disease Cancer Complex Traits Basic Biology |
| ELIXIR Cloud and AAI | Rare Disease Cancer Complex Traits Basic Biology |
| Human Cell Atlas | Rare Disease Cancer Complex Traits Basic Biology |
| ICGC ARGO | Cancer |
| Trans-Omics for Precision Medicine (TOPMed) | Rare Disease Complex Traits Basic Biology |
| EpiShare | Basic Biology |
| Genomics England | Rare Disease Cancer Complex Traits |