Widespread genomic data sharing between researchers and clinicians is crucial to maximise the utility of datasets and deliver better patient outcomes. However, sharing information across networks and countries increases the risk of a data breach. Strong approaches to security are paramount when working with genomic data. Crypt4GH is a file format that employs industry standards to keep genomic data secure.

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Benefits
- Allows data to be secure throughout its lifetime — from storage, to transfer, to analysis
- Can be added as an input file format to tools and applications
- Is supported by existing applications such as SAMTools
- Makes it easy to create files accessible to individual users
Target users
Researchers, and data custodians
Announcements
| Date | Title |
|---|---|
| 6 March 2026 | Join the next GIF “Ask Me Anything" event featuring Crypt4GH on 31 March! |
| 13 August 2024 | Large Scale Genomics (LSG) Work Stream Crypt4GH survey is now available |
| Title | Related Driver Projects and Organisations |
|---|---|
| All of Us Researcher Workbench | All of Us Research Program |
| EJP-RD Virtual Platform | European Joint Programme on Rare Disease (EJP RD) |
| ELIXIR European Genome-phenome Archive (EGA) | European Genome-phenome Archive (EGA) |
| ELIXIR-Beacon | ELIXIR Beacon |
| EpiShare Platform | EpiShare |
| Federated EGA | European Genome-phenome Archive (EGA), EMBL's European Bioinformatics Institute (EBI), Centre for Genomic Regulation |
| H3ABionet | Human Heredity and Health in Africa (H3Africa) |
Publications
| Title | Author(s) | Year |
|---|---|---|
| End-to-End Security for Local and Remote Human Genetic Data Applications at the EGA | 2019 |
Documents
| Date | Title |
|---|---|
| 29 April 2026 | GA4GH Implementation Forum (GIF) Ask Me Anything: Crypt4GH |
| 14 September 2023 | Code of Ethics and Community Conduct (CECC) |
| 11 March 2023 | Meeting minutes: Crypt4gh |
| 4 January 2022 | Meeting minutes: crypt4gh (2022) |
| 8 December 2020 | Meeting minutes: crypt4gh (2021) |
Contributors
Don't see your name..?
Get in touch- Robert DaviesGenetic Data Encryption (Crypt4GH) LeadWellcome Sanger Institute (WSI), Hinxton, UK
- Frédéric HazizaGenetic Data Encryption (Crypt4GH) LeadCentre for Genomic Regulation, Barcelona
- Dixie BakerMartin, Blanck and Associates
- Oliver HofmannUniversity of Melbourne Centre for Cancer Research, Melbourne
- John MarshallCentre for Population Genomics
- Martin PollardWellcome Sanger Institute (WSI), Hinxton, UK
Driver Projects
| Title | Thematic Area |
|---|---|
| All of Us Research Program | Rare Disease Cancer Complex Traits |
| Australian Genomics | Rare Disease Cancer Complex Traits |
| European Joint Programme on Rare Disease (EJP RD) | Rare Disease |
| Human Heredity and Health in Africa (H3Africa) | Complex Traits Basic Biology |
| ELIXIR Beacon | Rare Disease Cancer Complex Traits Basic Biology |
| European Genome-phenome Archive (EGA) | Rare Disease Cancer Complex Traits Basic Biology |
| EpiShare | Basic Biology |
Version history
| Version | Maintenance | Development | PDAP Review | Date |
|---|---|---|---|---|
| Crypt4GH v1.0 | Maintained | Development | Draft | 21 Oct 2019 |