Learn how GA4GH helps expand responsible genomic data use to benefit human health.
Learn how GA4GH helps expand responsible genomic data use to benefit human health.
Our Strategic Road Map defines strategies, standards, and policy frameworks to support responsible global use of genomic and related health data.
Discover how a meeting of 50 leaders in genomics and medicine led to an alliance uniting more than 5,000 individuals and organisations to benefit human health.
GA4GH Inc. is a not-for-profit organisation that supports the global GA4GH community.
To guide our collaborative, globe-spanning alliance, GA4GH relies on a Standards Steering Committee and an Executive Committee.
The Funders Forum brings together organisations that offer both financial support and strategic guidance.
The EDI Advisory Group responds to issues raised in the GA4GH community, finding equitable, inclusive ways to build products that benefit diverse groups.
Distributed across four Host Institutions, our staff team supports the mission and operations of GA4GH.
Curious who we are? Meet the people and organisations across six continents who make up GA4GH.
More than 500 organisations connected to genomics — in healthcare, research, patient advocacy, industry, and beyond — have signed onto the mission and vision of GA4GH as Organisational Members.
These core Organisational Members are genomic data initiatives that have committed resources to guide GA4GH work and pilot our products.
This subset of Organisational Members whose networks or infrastructure align with GA4GH priorities has made a long-term commitment to engaging with our community.
Local and national organisations assign experts to spend at least 30% of their time building GA4GH products.
Anyone working in genomics and related fields is invited to participate in our inclusive community by creating and using new products.
Wondering what GA4GH does? Learn how we find and overcome challenges to expanding responsible genomic data use for the benefit of human health.
Study Groups define needs. Participants survey the landscape of the genomics and health community and determine whether GA4GH can help.
Work Streams create products. Community members join together to develop technical standards, policy frameworks, and policy tools that overcome hurdles to international genomic data use.
GIF solves problems. Organisations in the forum pilot GA4GH products in real-world situations. Along the way, they troubleshoot products, suggest updates, and flag additional needs.
NIF finds challenges and opportunities in genomics at a global scale. National programmes meet to share best practices, avoid incompatabilities, and help translate genomics into benefits for human health.
Communities of Interest find challenges and opportunities in areas such as rare disease, cancer, and infectious disease. Participants pinpoint real-world problems that would benefit from broad data use.
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All GA4GH standards, frameworks, and tools follow the Product Development and Approval Process before being officially adopted.
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3 Oct 2018
The GA4GH 6th Plenary meeting was held at the Congress Center Basel in Basel, Switzerland and presented the first set of deliverables developed under GA4GH Connect — our five-year strategic plan to enable real-world genomic data sharing by 2022. We are grateful for the support of our local meeting sponsors, the SIB Swiss Institute of Bioinformatics and ELIXIR, who will co-host the meeting. Read more below.
The GA4GH 6th Plenary Meeting in Basel, Switzerland brought together more than 430 individuals representing more than 200 organizations across 25 countries to learn about new deliverables being developed under GA4GH Connect — a multi-year strategic phase focused on connecting GA4GH development work to the immediate data sharing needs of the genomics and health community. An additional 200+ individuals joined the meeting by live stream on October 4 and 5.
The first day of the GA4GH 6th Plenary Meeting focused primarily on topic-oriented workshops and ancillary meetings, with an introduction to the organization for those new to the community.
Ewan Birney (EMBL-EBI)
Millions of genomes will soon be available from healthcare and large scale genomics initiatives around the globe. To make best use of this data for human health and medicine, activities must be interoperable and thus built on common standards.
Peter Goodhand (OICR, GA4GH), Adrian Thorogood (McGill University, GA4GH), Melissa Konopko (Wellcome Sanger Institute, GA4GH), Rishi Nag (EMBL-EBI, GA4GH)
The Global Alliance for Genomics and Health (GA4GH) is the international standards organization for genomic data. It aims to accelerate progress in genomic science and human health by developing standards and framing policy for responsible genomic and health-related data sharing. Eight open, topic-oriented Work Streams are developing the standards and tools needed to achieve this mission, with direct input from GA4GH Driver Projects — real world genomic data initiatives that represent the broad genomics community and help develop and pilot GA4GH deliverables.
1. WORKSHOP: GENOMIC DATA COMPRESSION
Thomas Keane (EMBL-EBI), Marco Mattavelli (École Polytechnique Fédérale de Lausanne)
To discuss current approaches to genomic data compression and identify opportunities for collaboration.
2. GENE WORKSHOP: TRANSCRIPT CHOICE
Andy Yates (EMBL-EBI), Robert Freimuth (Mayo Clinic), Fiona Cunningham (EMBL-EBI)
A forum for discussion of the current progress for the work that the EMBL-EBI and NCBI have done jointly to harmonise a subset of transcripts.
3. GENE WORKSHOP: GENE-DISEASE VALIDITY
Heidi Rehm (Broad Institute), Ellen McDonagh (Genomics England)
To align all groups defining the validity of gene-based relationship, which informs their use of clinical testing, including the formation of gene panels.
4. ELIXIR Meeting
Serena Scollen (ELIXIR), Gary Saunders (ELIXIR), Michael Baudis (University of Zurich)
Presentation and discussion of ELIXIR and GA4GH collaborations, including an in depth ELIXIR Beacon Driver Project session.
5. WORKSHOP: DEMONSTRATING THE IMPACT OF GENOMIC DATA SHARING
Kathryn North (Murdoch Childrens Research Institute), Anna Middleton (Wellcome Sanger Institute)
To promote the positive impacts of genomic data sharing for the benefit of human health and medicine.
The second day of the GA4GH 6th Plenary Meeting was focused on enabling responsible genomic data sharing, with presentations from 13 active GA4GH contributors on work to date, a keynote talk from Andrew Morris (HDRUK), and panel discussions on the human right to benefit from data sharing and privacy and security.
Kathryn North (Murdoch Childrens Research Institute), Mark Caulfield (Genomics England)
Participants discussed key challenges facing large scale genomics initiatives around the globe, including harmonizing minimal clinical datasets, automated consent, and ongoing communication between National Initiatives.
Ewan Birney (EMBL-EBI)
The GA4GH Connect Strategic Roadmap lays out more than two dozen standards and deliverables to be added to the GA4GH suite to enable responsible genomic data sharing. These tools are designed to work together as an end-to-end solution for data sharing, but can also be used alone to solve a single challenge in an existing workflow. Each deliverable must pass through a product approval process to ensure it is fit for purpose and passes the ethics and security guidelines of the GA4GH foundational Work Streams.
Mike Lin (DNAnexus)
htsget provides a secure, consistent protocol for researchers to access data stored in different repositories — whether based in big public clouds or in more traditional infrastructure. It can be operated efficiently for very large datasets, and, because it uses the existing standards for transmitting data, it can be readily integrated into current pipelines and analytical methods. Users can employ htsget to download only the subsection of a genome sequence in which they are interested rather than the whole file, or they can download the entire genome as a series of “data slices” distributed across multiple disparate machines.
Thomas Keane (EMBL-EBI)
Housed at EMBL-EBI, the European Nucleotide Archive (ENA), European Genome-phenome Archive, and European Variant Archive provide the basic infrastructure to enable global public sharing of genetic data. Collectively, they form a single GA4GH Driver Project and each has implemented a subset of the existing GA4GH standards. In particular, EGA and RD-Connect (a global platform for rare-disease research, of which EGA is a partner) have implemented htsget, ENA has implemented refget, EGA has implemented the GA4GH Data Use Ontology and the ELIXIR Access and Authentication Infrastructure.
Andy Yates (EMBL-EBI)
The GA4GH refget API enables access to reference genomic sequences, without ambiguity from different sequence providers, using a checksum identifier based on the sequence content itself. This enables reliable, reproducible genomic analysis with clear provenance back to reference sequence.
4. Workflow Execution Service (WES)
David Glazer (Verily)
The GA4GH WES API lets users run a single workflow (defined using CWL or WDL) on multiple different platforms, clouds, and environments, and be confident that it will work the same way. The API provides methods to request that a workflow be run, pass parameters to that workflow, get information about running workflows, and cancel a running workflow.
5. Variant Interpretation for Cancer Consortium (VICC)
Alex Wagner (Washington University)
VICC is developing methods and tools for interoperability between knowledgebases containing clinical interpretations of cancer variants. Its ultimate clinical focus is for consensus expert curated interpretations to be integrated into clinical reports to improve consistency and outcomes in precision medicine.
6. Data Breach Reporting
Kate Birch (Australian Genomics)
The GA4GH Data Breach Response plan aims to ensure that GA4GH can respond in a timely and constructive way to breaches associated with GA4GH standards. Australian Genomics ran a data breach drill to test the efficacy of and improve on the GA4GH Data Breach Response protocol.
7. Regulatory and Ethics Work Stream
Madeleine Murtagh (Newcastle University)
The GA4GH REWS toolkit currently includes a consent policy template/clauses, consent codes, access and discovery matrix, registered access, privacy and security guidance, genomic data lexicon, accountability policy, and ethics review equivalency policy. In addition to developing a regulatory and ethics review process of all GA4GH technical deliverables, the group is working on a survey (Your DNA, Your Say) to probe public views of genomic data sharing internationally and hosting a forum to provide expert guidance on GDPR for health data sharing.
Jules Jacobsen (Queen Mary University of London)
Phenopackets is an open standard for sharing disease and phenotype information by linking detailed phenotype descriptions with disease, patient, and genetic information. It enables clinicians, biologists, and disease and drug researchers to build more complete models of disease.
9. Scaling Genomic Data Knowledge
Heidi Rehm (Broad Institute of MIT and Harvard)
Standards and consensus on knowledge representation are needed to support the interpretation of variants and determine which genes are valid disease genes, ready for clinical testing. The GA4GH Genomic Knowledge Standards Work Stream (GKS) is developing a framework of standards-based components that lower barriers for the exchange of genomic information and its translation into clinical practice. GKS is focused on genetic variant representation and annotation as well as gene annotation.
10. Search API
Harindra Arachchi (Broad Institute of MIT and Harvard)
The GA4GH Search API provides a flexible, extendable interface to query a federated network of patient genomic databases.
11. Data Use Ontology (DUO)
Melanie Courtot (EMBL-EBI), Moran Cabili (Broad Institute of MIT and Harvard)
DUO allows data holders to semantically tag datasets with restrictions about their usage, making them automatically discoverable based on the intended usage. It enables machine readable descriptions of data access requests and data use restrictions to be matched, and would ultimately alleviate the need for manual review when datasets are requested by researchers. DUO is a product of the Data Use and Researcher Identity work stream and is available at https://github.com/EBISPOT/DUO.
12. Researcher Identities
Stephanie Dyke (McGill University), Ilia Tulchinksy (Google)
The GA4GH Researcher Identity and Bona Fide Researcher Claims Standard will allow researchers and other users to establish identity and credentials claims with regards to their professional identity to acquire access across datasets.
13. Beacon API
Marc Fiume (DNAstack)
The Beacon API is a web-accessible service that users may query for information about a specific allele. V1.0,0 extends Beacon’s functionality through support for additional types of genomic variants and improved metadata support.
Andrew Morris (HDRUK)
Health Data Research UK (HDRUK) seeks to create a thriving, high-energy UK-wide network of inter-disciplinary research expertise that will disrupt traditional science by enabling new scientific discovery from large multi-dimensional datasets, apply cutting-edge technologies to enhance science, innovation and decision making, and improve healthcare for a population of 65 million people.
1. Your DNA, Your Say
Anna Middleton (Wellcome Genome Campus)
Created by the GA4GH Participant Values Task Team on behalf of the Regulatory and Ethics Work Stream, Your DNA, Your Say is a global online survey gathering public attitudes towards genomic data sharing. The survey contains nine innovative films that explain what genomic data sharing is through the eyes of a little boy called Charlie and have been translated into ten languages with more forthcoming.
2. A View from Molecular Oncology: ICGC-ARGO
Peter Lichter (German Cancer Research Center)
The Pan-cancer Analysis of Whole Genomes Project (PCAWG) was an international collaboration to identify common patterns of mutation in more than 2,800 cancer whole genomes from the International Cancer Genome Consortium (ICGC). Now ICGC-ARGO (Accelerating Research in Genomic Oncology) aims to expand that work by sequencing samples from at least 100,000 cancer patients in the context of clinical studies over the next decade.
3. Implications for Responsible Genomic Data Sharing
Rumiana Yotova (University of Cambridge)
The right to benefit from science was first set out in the 1948 Universal Declaration of Human Rights and later affirmed in the International Covenant on Economic, Social and Cultural Rights. This right has important implications for responsible genomic data sharing, namely, it imposes an obligation on States to enable access to scientific knowledge and data freely and without discrimination, to protect the freedom of scientific research, as well as to ensure that the right to benefit from science is exercised in a manner respectful of human rights, including the right to privacy and to prior informed consent.
Chair: Madeleine Murtagh (Newcastle University)
Speakers in the Right to Benefit session discussed issues of research across national borders and linkages between science and the commercial sector.
1. Data Protection for Personalized Health (DPPH)
Jean Pierre Hubaux (École Polytechnique Fédérale de Lausanne)
DPPH is a Swiss response to growing concerns about health data privacy. it is a project whose goals are highly aligned with those of GA4GH, dimensioned for the Swiss scale, but with an international vision. With participation from five research groups across the ETH Domain and the Swiss Data Sciences Center, the project will (i) address the main privacy, security, scalability, and ethical challenges of data sharing for enabling effective P4 medicine; (ii) define an optimal balance between usability, scalability and data protection, and (iii) deploy an appropriate set of computing tools.
2. Making New Treatments Possible: The GDPR Code of Conduct for Health Research Initiative
Michaela Mayrhofer (BBMRI-ERIC)
The GDPR Code of Conduct for Health Research Initiative aims to (i) contribute to the proper application of the GDPR in the area of health; (ii) clarify and specify certain rules of the GDPR for scientiﬁc research in the area of health; (iii) demonstrate GDPR compliance and (iii) foster transparency and trust in the use of personal data in the area of health research.
3. Systemic Oversight of Big Data Health Research
Alessandro Blasimme (ETH-Zurich)
The health data ecosystem is evolving in the era of genomics and digital health, resulting in emerging challenges in areas such as consent, IRB/REC, and data protection. Systemic oversight is needed to foster an ethical common ground for a variety of governance actors and activities and to ensure distributed accountability throughout the data ecosystem.
Chair: Paul Flicek (EMBL-EBI)
Speakers in the Privacy and Security session discussed data access conditions, the responsibility to share data for the benefit of the community, balancing data encryption and protection with utility, and the ethics of sharing un-consented data.
The final day of the GA4GH 6th Plenary Meeting focused on “going global,” with the announcement of an open call for new GA4GH Driver Project applications to increase the organization’s international representation. Keynotes from Torsten Schwede (SIB-Swiss Institute for Bioinformatics) and Nicola Mulder (University of Cape Town) introduced the community to activities ongoing in Switzerland and on the African continent. Panel discussions focused on the patient perspective, alignment across standards organizations, and national initiatives.
Ewan Birney (EMBL-EBI), Peter Goodhand (OICR)
GA4GH will accept applications for new Driver Projects until November 1, 2018 with a specific focus on global representation, scientific merit, and capacity to contribute. Up to five new projects will be announced in January 2019.
1. Swiss Personalized Health Network
Torsten Schwede (SIB-Swiss Institute for Bioinformatics)
SPHN aims to bring Switzerland to the forefront of personalized health research by establishing nationwide interoperability of biomedical information. It establishes a dynamic network of interoperable and sharable resources (data, platforms, workflows, competences) distributed across the cantons and supported by national coordination.
Nicola Mulder (University of Cape Town)
A representative dataset of African genomes is critical both to address diseases that disproportionately affect the African continent as well as to improve research and healthcare globally. Human Heredity & Health in Africa (H3Africa) aims to facilitate an African-based research approach to the study of genomic and environmental determinants of common diseases with the goal of improving the health of African populations.
Heidi Rehm (Broad Institute of MIT and Harvard)
Rehm highlighted stories of patients catalyzing research on their diseases, as well as a series of platforms to assist in this pursuit.
Peter Kapitein (Inspire2Live)
The international Inspire2Live Patient Advocates organization inspires people (patients, clinicians and researchers), without limitations, to work together to get cancer under control by 2021 and to lead happy and healthy lives in harmony with cancer. Our Patient Advocates are leading in this process.
2. BLACKSWAN Foundation
Olivier Menzel (BLACKSWAN Foundation)
The BLACKSWAN Foundation was established in Switzerland in 2010 to contribute to the development of research on rare and orphan diseases worldwide. Besides its funding research mission, the Foundation organizes the bi-annual RE(ACT) Congress, an international reference point for rare disease experts as well as an international advocacy and awareness campaign called #RAREvolution to ensure rare diseases are recognized as an international public health and research priority.
3. Count Me In: Partnering with Patients to Accelerate Cancer Research
Corrie Painter (Broad Institute of MIT and Harvard)
Count Me In aims to generate a massive publicly available database of clinical, genomic, molecular, and patient reported data in cancer to accelerate discoveries and the development of new treatment strategies. Engaging with patients to directly partner with them on cancer research, CMI has launched open clinical-genomic databases to improve research on three specific diseases: Metastatic Breast Cancer, Angiosarcoma, Metastatic Prostate Cancer, and Gastroesophageal Cancer.
Chair: Heidi Rehm (Broad Institute of MIT and Harvard)
Speakers in the Patient Perspectives session discussed expanding patient engagement to more countries and across more disease areas and using these efforts to recruit for clinical trials, returning results to patients, integrating environmental data into patient surveys, and the right to try medications still in trial phase.
The BRCA Exchange aims to advance our understanding of the genetic basis of breast cancer, ovarian cancer and other diseases by pooling data on BRCA1/2 genetic variants and corresponding clinical
Robert Freimuth (Mayo Clinic)
Health Level 7 (HL7) International develops standards for transfer of clinical and administrative data between software applications used by healthcare providers and clinical systems. The HL7 Clinical Genomics Work Group (CG WG) facilitates the development of standards for the exchange of clinical and translational information related to an individual’s genomic data and family health history, and (its linkage to) relevant clinical information. The HL7 CG and the GA4GH Genomic Knowledge Standards Work Stream are coordinating on the development of compatible standards that will enable the translation of genomic data and knowledge from the research to the clinical domain.
2. SNOMED CT
Ian Green (SNOMED CT)
Owned and governed by 36 Member countries, SNOMED International (formerly IHTSDO) is a not-for-profit organization charged with setting global standards for health terminology, a critical element of safe and effective healthcare. SNOMED CT is an ontological resource with comprehensive, scientifically validated clinical content that enables consistent representation of clinical content for processing in electronic health records. It maps to other international standards and is used in more than fifty countries.
3. Clinical Data Interchange Standards Consortium
Peter Van Reusel (CDISC)
CDISC is Global Standards Development Organization (SDO) founded in 1997 by volunteers and incorporated as a non-profit organization in 2000. It aims to develop and support global, platform-independent data standards that enable information system interoperability to improve medical research and related areas of healthcare.
4. ISO/TC 215 Genomics & NCI Terminology Standards for Health Informatics
Bron Kisler (NIH)
ISO Technical Committee 215 (TC215): Health Informatics was founded in 1998 to achieve standardization in the field of health informatics to facilitate the coherent and consistent interchange and use of health-related data, information, and knowledge to support and enable all aspects of the health system.
5. Industry Perspective: Roche Sequencing Solutions
Chris Bakan (Roche)
6. UK’s 100,000 Genomes Project: Clinical and Research Uses
Augusto Rendon (Genomics England)
There is a gap between the number of sequences collected by Genomics England to date and the number of sequences that have been analysed. This gap is due in part to “fragile interoperability,” wherein a specification is either insufficient or not enforced, making it difficult to share data across platforms and make it available for analysis.
Kathryn North (Murdoch Childrens Research Institute)
With GA4GH Connect, the Global Alliance for Genomics and Health is bringing together leading genomic data initiatives as Driver Projects to help develop and pilot standards most needed by the community. Input from national genomic data initiatives around the globe are critical to this endeavour. Under the banner of GA4GH, Australian Genomics and Genomics England have already begun to share knowledge and resources and seek to include more initiatives in this endeavour to exchange learnings for the benefit of all.
1. Genomics England
Mark Caulfield (Genomics England)
The 100,000 Genomes Project is a UK Government project that is sequencing whole genomes through the National Health Service to enable scientific discovery and medical insights, with an initial focus on rare diseases and some common types of cancer. On October 2, 2018, the UK Government announced a plan to expand this project to collect 5 million genomes.
2. Australian Genomics
Kathryn North (Murdoch Childrens Research Institute)
Australian Genomics is a national research collaboration of clinicians, researchers and diagnostic geneticists working together to provide evidence for the equitable, effective and sustainable delivery of genomic medicine in healthcare. Australian Genomics unites 80 partner institutions across the country.
3. All of Us
Chris Lunt (NIH)
The All of Us Research Program is a historic, longitudinal effort to gather data from one million or more people living in the United States to accelerate research and improve health. By taking into account individual differences in lifestyle, socioeconomics, environment, and biology, researchers will uncover paths toward delivering precision medicine.
4. Japan Agency for Medical Research and Development (AMED)
Hidewaki Nakagawa (RIKEN)
The Japan Agency for Medical Research and Development (AMED) promotes integrated research and development in the field of medicine, from basic research to clinical trials. AMED is currently exploring the possibility of a Japanese genome umbrella project that would bring together several large research projects from around the country, including the Tohoku Medical Megabank Project and the BioBank Japan Project.
5. Plan France Médecine Génomique 2025
Anne Cambon-Thomsen (CNRS, Inserm and University Toulouse III Paul Sabatier)
Under the leadership of the Alliance of French Institutions for Life Sciences and Health (AVIESAN), Plan France Médecine Génomique 2025 aims to integrate genomic sequencing into generic healthcare and develop a national genomic medicine sector by 2025. It has three major objectives: (i) set up the tools for a genomic healthcare pathway, (ii) ensure these developments take place in a safe technical and ethical framework, and (iii) implement monitoring and management tools.
6. The Finnish National Initiative
Ilka Lappalainen (ELIXIR-Finland)
With a population of 5.4 million, Finland provides national healthcare to each citizen. Over the past 15 years, healthcare funding has increased from 7% to 9.5% of national gross income. A number of national registries, biobanks and digital health information are already available and could be connected using a national security identifier. An effective national genome strategy would have a significant impact on healthcare, promote innovation, and make the data collected through healthcare data available for research in a secure manner.
Ewan Birney (EMBL-EBI)
Birney closed the 6th Plenary Meeting of the Global Alliance for Genomics and Health with an announcement of the next meeting, which will take place in the US from October 21 – 23, 2019.
“This is a community that I think can change the world and that I’m very proud to be a part of.”
Thank you to the Programme Committee who made this meeting possible:
Thank you to the GA4GH 2018 Funding Partners whose support made GA4GH 6th Plenary possible.
Funding for this meeting was made possible in part by a supplement to U41HG006834 from the National Institutes for Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.