Trans-Omics for Precision Medicine (TOPMed)

Integrates sequencing and “omics” data into large studies of human health data

Trans-Omics for Precision Medicine (TOPMed) aims to integrate whole-genome sequencing and data from other “omics” (such as epigenomics or protein expression) into larger studies with rich stores of molecular, behavioural, imaging, environmental, and clinical data. This initiative of the National Heart, Lung, and Blood Institute at the U.S. National Institutes of Health focuses on heart, lung, blood, and sleep disorders.

Trans-Omics for Precision Medicine (TOPMed) information
Driver Project Website
Thematic Area
  • Albert Smith
  • Alastair Thomson
  • Weiniu Gan
Share your implementation

GA4GH implementations

See how this Driver Project uses our products in the real world.
Curious how they did it? Contact the project directly.

NHLBI TOPMed BioData Catalyst

This is a full implementation of the DRS v1.1 standard with support for persistent identifiers. The open-source DRS server follows the Gen3 implementation. Gen3 is a GA4GH-compliant, open-source platform for developing framework services and data commons. Data commons accelerate and democratize the process of scientific discovery, especially over large or complex datasets. Gen3 is maintained by the Center for Translational Data Science at the University of Chicago.