From 16 to 17 November 2021, initiatives from around the globe convened for a meeting of the Genomics in Health Implementation Forum (GHIF). The GHIF aims to support accurate data interpretation, diagnosis, and innovative solutions through global cooperation in data sharing and the clinical implementation of genomics. The forum helps initiatives reduce duplication of efforts and promote the collection of compatible clinical genomic data and health information to enable data sharing. Our primary focus is to support the uptake of GA4GH standards and provide real-world insights to the GA4GH Work Streams as they develop new standards to support data sharing.